I know the simpsons have been around longer but I'm a Family Guy fan all the way and I've never really got into the simpsons so I'm Lois all the way. To add to that, Lois is my favorite cartoon ever ~ She is so awesome
It depends on the situation for me. I mean look at what you're dealing with;
Lois: Master of Tae Jitsu, has been shot multiple times and lived, lives through Stewie's various matricidal attacks, wealthy parents give her many connections, she's been to prison.
Marge: Ex bodybuilder who was able to lift up a bus, has proven able to outwit the entire US Millitary and Lisa on occasion, she beat the devil in a court proceeding, and she too has been to prison, more times than Lois I think.
I'd side with Lois probably becuase she's probably faster and can take a bit more abuse over a long period. Marge can't make the same claim.